Treatment results and prognostic factors in inoperable carcinoma of the cervix treated with external plus high dose brachytherapy

Garipagaoglu M., YALVAÇ E. S. , Kose M., Tulunay G., Kayikcioglu F., Cakmak A., ...More

CANCER LETTERS, vol.136, no.1, pp.17-26, 1999 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 136 Issue: 1
  • Publication Date: 1999
  • Doi Number: 10.1016/s0304-3835(98)00293-6
  • Title of Journal : CANCER LETTERS
  • Page Numbers: pp.17-26
  • Keywords: inoperable cervical carcinoma, prognostic criteria, high dose rate brachytherapy, SQUAMOUS-CELL CARCINOMA, UTERINE CERVIX, RADIATION-THERAPY, STAGE IB, CLINICAL-DATA, CANCER, 5-FLUOROURACIL, IRRADIATION, SURVIVAL, PATTERNS


Patients with inoperable carcinoma of the cervix treated with external plus high dose rate brachytherapy (HDRB), between 1988 and 1995 were evaluated retrospectively. According to stage, 5 year survival rates were 67.3% in stage IIb and 52.6% in stage III (P = 0001) and disease free survival (DFS) rates were 54.0% in stage IIb and 43.9% in stage III (P = 0.01), The following parameters were studied: age; stage; external beam dose; brachytherapy dose; total dose to point A; tumor mass; tumor response rate; bilateral or unilateral invasion of parametria in stage IIb; and bilateral or unilateral invasion of pelvic wall in stage mb; and the existence of hydronephrosis. The only significant parameter of 5 year survival and local control was tumor mass (P = 0.003). (C) 1999 Published by Elsevier Science Ireland Ltd, All rights reserved.