Relation of thyroid disfunction, thyroid autoantibodies, and renal function


Suher M., Koc E., Ata N., Ensari C.

Renal Failure, vol.27, no.6, pp.739-742, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 6
  • Publication Date: 2005
  • Doi Number: 10.1080/08860220500243338
  • Journal Name: Renal Failure
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.739-742
  • Keywords: Renal function, Thyroid autoantibodies, Thyroid autoimmunity, Thyroid dysfunction
  • Yozgat Bozok University Affiliated: No

Abstract

Fifty-eight patients with thyroid dysfunction were included, comparing 27 healthy subjects to evaluate the relationship between thyroid autoimmunity, thyroid functional status, and renal function. Regardless of clinical status, hypothyroidism was defined as T3-T4 upper limit of normal, and hyperthyroidism was defined as T3-T4>normal limits and TSH p = 0.05). In hypothyroid patients, UAER was significantly higher than in hyperthyroid patients and control subjects (30.1 mg/day, 11.8 mg/day, 10.5 mg/day, respectively; p<0.001). In the hypothyroid population, with regard to UAER and CC, we could not find a significant difference between the thyroid autoantibody positive and negative groups. In view of CC, hypothyroid patients had significantly lower CC than the hyperthyroid group (79.0 mL/min, 86.5 mL/min, respectively; p<0.01). A careful control of the renal function in thyroid diseases should be evaluated. Renal dysfunction seems to be secondary to hypothyroidism rather than thyroid autoimmunity. Copyright © 2005 Taylor & Francis Inc.