In this study, a high sensitive metamaterial sensor has been designed to detect quality of water for water treatment centre. The water samples have been obtained and electrical properties have been measured in microwave range to design the proposed sensor. These electrical properties have been assigned in microwave simulator. Water quality has been investigated by using parametric study and genetic algorithm approach to realize high sensitivity in terms of resonance frequency shift. Around 130 MHz frequency shift has been observed between the water samples. This shift is sufficient to detect instantaneously to the quality of water. This is the first study that metamaterial approach has been used to detect water quality in literature.