Comparison of Low-Dose Oxytocin and Dinoprostone for Labor Induction in Postterm Pregnancies: A Randomized Controlled Prospective Study

Akay N. O., Hizli D., Yilmaz S. S., YALVAÇ E. S., Kandemir O.

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, vol.73, no.3, pp.242-247, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1159/000334404
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.242-247
  • Keywords: Postterm pregnancy, Oxytocin, Dinoprostone, Labor induction, TERM PREMATURE RUPTURE, MISOPROSTOL, TRIAL
  • Yozgat Bozok University Affiliated: No


Aims: The aim of this study was to compare the efficacy of oxytocin and dinoprostone in achieving successful labor induction and vaginal delivery in postterm women with an unfavorable cervix. Methods: Postterm women with an uncomplicated pregnancy and a Bishop score of <= 6 were randomized to receive either dinoprostone vaginal pessary (Propess (R)) or low-dose oxytocin. The primary outcomes were the length of the induction-to-delivery period and the incidence of vaginal delivery. Results: A total of 144 women were available for the analysis. The overall vaginal delivery rates were 75% (54/72) for the dinoprostone group and 80.6% (58/72; p = 0.35) for the oxytocin group; the mean induction-to-vaginal delivery interval was 13.3 and 10.3 h in the dinoprostone and the oxytocin group, respectively (p = 0.003). Uterine hyperstimulation was 7.4% compared with 6.8% (p = 0.8), and abnormal fetal heart rate was 26.4% compared with 18% (p = 0.2), respectively. Conclusion: Both oxytocin and dinoprostone seem to have similar obstetric outcomes in postterm pregnancies with an unfavorable cervix, except for a significant superiority of oxytocin for delivery in a shorter period. Copyright (C) 2012 S. Karger AG, Basel