Aim of this study is to investigate the impact of carboxymetylcellulose about adhesion formation, fibrosis and inflamation after thyroid region surgery in an animal model. Forty rats were grouped into four and a cervical midline skin incision was made. Both thyroid lobe were seen and they were sutured two times per lobe with silk suture in group I, II, III and IV. In addition this procesure a sheet of the Carboxymethylcellulose (CMC) membrane was placed on thyroid glands before closing in goup III and IV. Rats were sacrified at seventh day in groups I, III and at twenty-eighth day in groups II, IV. In all groups adhesion formation, fibrosis and inflamation were evaluated and compared statistically. The comparison of groups in terms of macroscopic adhesion, fibrosis and inflammation scores revealed a statistically significant difference between Group I and Group III, and Group II and Group IV. (P<0,0001) Severe fibroblast proliferation was seen in the control groups and minimal fibroblast proliferation was seen in CMC membrane groups. CMC usage may be proceed to avoid from adhesion in reexploration expected thyroid surgery.