Objectives: The study investigated the relationship between fear of COVID-19, quality of sexual life, and sexual satisfaction of women in Turkey. Methods: This cross-sectional study was conducted between November 26, 2020, and January 26, 2021. The sample consisted of 811 women. Data were collected using the Fear of COVID-19 Scale, the Sexual Quality of Life-Female Scale, and the Pre-Pandemic Sexual Satisfaction and During Pandemic Sexual Satisfaction scores. Results: There was a negative correlation between the Fear of COVID-19 Scale and the Sexual Quality of Life-Female Scale and the During Pandemic Sexual Satisfaction scores. The Fear of COVID-19 Scale scores accounted for 86% of the total variance in the Sexual Quality of Life scores and 5% of the total variance in the During Pandemic Sexual Satisfaction Scores. Conclusion: Sexual problems due to the fear of COVID-19 adversely affect women's sexual quality of life. Healthcare professionals should address the fear of COVID-19 and related sexual issues during the pandemic.