Hematoprotective effect of vitamins C and E against subchronic toxicity of bendiocarb: Biochemical evidences


APAYDIN F. G. , PANDIR D. , KALENDER S., BAŞ H. , KALENDER Y.

JOURNAL OF FOOD BIOCHEMISTRY, vol.42, no.6, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1111/jfbc.12659
  • Title of Journal : JOURNAL OF FOOD BIOCHEMISTRY

Abstract

Oxidative stress parameters were tested in blood samples obtained from bendiocarb, vitamin C- and vitamin E-treated rats and evaluated for lipid peroxidation and antioxidant enzymes. Hematologic parameters, ferric reducing antioxidant potential (FRAP) and trolox equivalent antioxidant capacity (TEAC) levels were also assayed in rat blood. The levels of malondialdehyde of erythrocytes and leucocytes, white blood cell (WBC), mean platelet volume (MPV) and platelet values increased, and glutathione peroxidase, superoxide dismutase, glutathione-S-transferase, catalase activities of erythrocytes and leucocytes, FRAP and TEAC values decreased in bendiocarb-treated group. There were ameliorative effects of vitamins C and E on examining parameters. There were no significant differences between vitamin C, vitamin E and vitamin C + vitamin E treatment on changes caused by bendiocarb in GPx and GST activities, and WBC, MPV and platelet values. The present results suggest that reduced FRAP and TEAC values and antioxidant enzyme activities, enhanced lipid peroxidation, WBC, MPV, and platelet levels in the blood were handled in the context of oxidative stress.