Protective effects of propolis on methotrexate-induced testis injury in rat


Sonmez M. F. , Cilenk K. T. , KARABULUT D., Unalmis S., Deligonul E., Ozturk I., ...More

BIOMEDICINE & PHARMACOTHERAPY, vol.79, pp.44-51, 2016 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 79
  • Publication Date: 2016
  • Doi Number: 10.1016/j.biopha.2016.02.002
  • Title of Journal : BIOMEDICINE & PHARMACOTHERAPY
  • Page Numbers: pp.44-51
  • Keywords: Methotrexate, Propolis, HSP-70, Apoptosis, Testis, INDUCED TESTICULAR TOXICITY, INDUCED OXIDATIVE STRESS, ACID PHENETHYL ESTER, HEAT-SHOCK-PROTEIN, GERM-CELLS, OSTEOSARCOMA, GENOTOXICITY, EXPRESSION, MELATONIN, EXTRACT

Abstract

Propolis is an adhesive substance which is collected and used by honeybees. Propolis is a potent antioxidant and a free radical scavenger. This study was designed to determine whether propolis could protect against dysfunction and oxidative stress induced by methotrexate-induced injury in rat testis.