Development of HPLC Methods for Individual Determination of 20 Active Pharmaceutical Ingredients for Ussing-Chamber Studies

KAYNAK M. S., Akgeyik E., ATEŞ M., ÇELEBİER M., ŞAHİN S.

CURRENT PHARMACEUTICAL ANALYSIS, vol.13, no.2, pp.145-153, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.2174/1573412912666161018145031
  • Journal Name: CURRENT PHARMACEUTICAL ANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.145-153
  • Keywords: HPLC, ussing-chamber, krebs buffer, active pharmaceutical ingredient, method development, DRUG-DRUG INTERACTION, TISSUE DISTRIBUTION, PERMEABILITY
  • Yozgat Bozok University Affiliated: No

Abstract

Background: The aim of this study was to develop HPLC methods for individual determination of 20 active pharmaceutical ingredients (amoxicillin sodium, antipyrine, atenolol, caffeine, carbamazepine, cimetidine, enalapril, furosemide, hydrochlorothiazide, ibuprofen, ketoprofen, metoprolol tartrate, methyldopa, naproxen sodium, pindolol, piroxicam, propranolol HCl, ranitidine, theophylline, and verapamil HCl) to be used for determination of their intestinal permeabilities across Ussing-Chamber.