Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer's disease: An update

Villa C., Suphesiz H., Combi R., Akyuz E.

MECHANISMS OF AGEING AND DEVELOPMENT, cilt.185, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 185
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.mad.2019.111197
  • Dergi Adı: MECHANISMS OF AGEING AND DEVELOPMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Abstracts in Social Gerontology, BIOSIS, Business Source Elite, Business Source Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

With more than 80 subunits, potassium (K+) channels represent a group of ion channels showing high degree of diversity and ubiquity. They play important role in the control of membrane depolarization and cell excitability in several tissues, including the brain. Controlling the intracellular and extracellular K+ flow in cells, they also modulate the hormone and neurotransmitter release, apoptosis and cell proliferation. It is therefore not sur- prising that an improper functioning of K+ channels in neurons has been associated with pathophysiology of a wide range of neurological disorders, especially Alzheimer's disease (AD).