Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer's disease: An update


Villa C., Suphesiz H., Combi R., Akyuz E.

MECHANISMS OF AGEING AND DEVELOPMENT, vol.185, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 185
  • Publication Date: 2020
  • Doi Number: 10.1016/j.mad.2019.111197
  • Title of Journal : MECHANISMS OF AGEING AND DEVELOPMENT

Abstract

With more than 80 subunits, potassium (K+) channels represent a group of ion channels showing high degree of diversity and ubiquity. They play important role in the control of membrane depolarization and cell excitability in several tissues, including the brain. Controlling the intracellular and extracellular K+ flow in cells, they also modulate the hormone and neurotransmitter release, apoptosis and cell proliferation. It is therefore not sur- prising that an improper functioning of K+ channels in neurons has been associated with pathophysiology of a wide range of neurological disorders, especially Alzheimer's disease (AD).