Assessment of nitric oxide, advanced oxidation protein products, malondialdehyde, and thiol levels in patients with restless legs syndrome


BAŞKOL G., Korkmaz S., Erdem F., CANİKLİOĞLU A. , Kocyigit M., Aksu M.

SLEEP MEDICINE, vol.13, no.4, pp.414-418, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1016/j.sleep.2011.11.012
  • Title of Journal : SLEEP MEDICINE
  • Page Numbers: pp.414-418
  • Keywords: Restless legs syndrome, Nitric oxide, Malondialdehyde, Advanced oxidation protein products, LIPID-PEROXIDATION, ENDOTHELIAL DYSFUNCTION, DOPAMINE TRANSPORTER, STRESS, DISEASE, ANTIOXIDANTS, STRIATUM, BIOCHEMISTRY, INFLAMMATION, DIAGNOSIS

Abstract

Objectives: We aimed to determine the importance of oxidative stress in the pathogenesis of restless legs syndrome (RLS) by quantification of advanced oxidation protein products and total thiol levels (as markers of oxidative protein damage), nitric oxide levels (as an antioxidant and endothelial function), and malondialdehyde levels (as a marker of lipid peroxidation) in patients with RLS.