The protective effect of JZL184 on ovarian ischemia reperfusion injury and ovarian reserve in rats


Caltekin M. D. , Ozkut M. M. , Caltekin I. , KAYMAK E., ÇAKIR M., Kara M. , ...More

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol.47, no.8, pp.2692-2704, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 8
  • Publication Date: 2021
  • Doi Number: 10.1111/jog.14859
  • Title of Journal : JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
  • Page Numbers: pp.2692-2704
  • Keywords: endocannabinoid, inflammation, ischemia reperfusion, ovarian reserve, ovary, oxidative stress, MULLERIAN HORMONE-LEVELS, ISCHEMIA/REPERFUSION INJURY, ENDOCANNABINOID SYSTEM, TESTICULAR TORSION, CANNABINOIDS, DETORSION, ACID, INHIBITION, ANANDAMIDE, HYDROLASE

Abstract

Aim Ovarian torsion is a gynecopathology that requires emergency surgery in women. However, ischemia reperfusion injury (IRI) occurs after treatment with detorsion. This study aimed to evaluate the effects of monoacylglycerol lipase inhibitor JZL184 on ovarian IRI and ovarian reserve.