A critical role for expression of atypical chemokine receptor 2 in multiple sclerosis: A preliminary project


SAÇMACI H. , SABAH ÖZCAN S.

MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol.38, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38
  • Publication Date: 2020
  • Doi Number: 10.1016/j.msard.2019.101524
  • Title of Journal : MULTIPLE SCLEROSIS AND RELATED DISORDERS

Abstract

Background: : ACKR2 is an atypical chemokine receptor that promotes acute inflammation by acing as a scavenger receptor for inflammatory chemokines in experimental models of some inflammatory disorders, but its function in multiple sclerosis (MS) is unclear. Therefore we aimed to evaluate the mRNA expression of ACKR2 as a scavenger receptor in patients with MS and also the correlation of this expression with certain cytokines that are important for MS pathogenesis.