This work was planned to research the effects of lipopolysaccharide (LPS) and/or vitamin E(VE) and sodium selenite (SS), which have antioxidant properties, administered to the liver tissue of male rats. For this purpose, histopathology, immunohistochemistry, antioxidant capacity, terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling assay, liver function, and DNA structure tests were performed. The lipid profile was also evaluated in this study. Rats that were administered LPS were treated with VE and/or SS. The liver function tests and lipid profile parameters showed statistically significant changes and histological alterations in the LPS treated groups. The number of cells entering apoptosis was increased by LPS administration when compared to the control group. LPS treatment increased the DNA damage and decreased the ferric reducing antioxidant power and trolox equivalent antioxidant capacity values when compared to the control group. VE and/or SS provided protective effects against the examined parameters. These results indicated that we can assume that the treatment of VE and SS together may be more efficient than using them individually against LPS.