Elevated serum arginase activity levels in patients with breast cancer


Polat M. F. , Taysi S., Polat S., Boyuk A., Bakan E.

SURGERY TODAY, vol.33, no.9, pp.655-661, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 9
  • Publication Date: 2003
  • Doi Number: 10.1007/s00595-002-2563-2
  • Title of Journal : SURGERY TODAY
  • Page Numbers: pp.655-661
  • Keywords: breast cancer, tumor marker, enzyme, arginase activity, HUMAN COLORECTAL-CANCER, GASTRIC-CANCER, CELL-LINES, CARCINOMA, TISSUES, MARKERS, BLOOD, TUMOR

Abstract

Purpose. Recently, the high activity of arginase enzyme has been observed in the sera of malignant neoplasms. In this pathogenic condition, it is said that arginase strongly inhibits lymphocyte proliferation and plays a role in providing ornithine as a substrate for biosynthesis of polyamines, which have been found in various types of cancer. The aim of this study was to examine the arginase activity levels in breast cancer as a marker.