Partial changes in apoptotic pathways in hippocampus and hypothalamus of Cc2d1a heterozygous

ŞENER E. F., Dana H., Tahtasakal R., HAMURCU Z., Guler A., Tufan E., ...Daha Fazla

METABOLIC BRAIN DISEASE, cilt.38, sa.2, ss.531-541, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s11011-022-01125-y
  • Dergi Adı: METABOLIC BRAIN DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.531-541
  • Anahtar Kelimeler: Autism, Hippocampus, Hypothalamus, Apoptosis, Cc2d1a, Mouse, SEX-DIFFERENCES, CASPASE-3, ACTIVATION, DEPRESSION, BEHAVIORS, BRAIN, MODEL
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Alterations in the apoptosis pathway have been linked to changes in serotonin levels seen in autistic patients. Cc2d1a is a repressor of the HTR1A gene involved in the serotonin pathway. The hippocampus and hypothalamus of Cc2d1a +/- mice were analyzed for the expression of apoptosis markers (caspase 3, 8 and 9). Gender differences were observed in the expression levels of the three caspases consistent with some altered activity in the open-field assay. The number of apoptotic cells was significantly increased. We concluded that apoptotic pathways are only partially affected in the pathogenesis of the Cc2d1a heterozygous mouse model.