Partial changes in apoptotic pathways in hippocampus and hypothalamus of Cc2d1a heterozygous
METABOLIC BRAIN DISEASE, cilt.38, sa.2, ss.531-541, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 38 Sayı: 2
- Basım Tarihi: 2023
- Doi Numarası: 10.1007/s11011-022-01125-y
- Dergi Adı: METABOLIC BRAIN DISEASE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
- Sayfa Sayıları: ss.531-541
- Anahtar Kelimeler: Autism, Hippocampus, Hypothalamus, Apoptosis, Cc2d1a, Mouse, SEX-DIFFERENCES, CASPASE-3, ACTIVATION, DEPRESSION, BEHAVIORS, BRAIN, MODEL
- Yozgat Bozok Üniversitesi Adresli: Evet
Özet
Alterations in the apoptosis pathway have been linked to changes in serotonin levels seen in autistic patients. Cc2d1a is a repressor of the HTR1A gene involved in the serotonin pathway. The hippocampus and hypothalamus of Cc2d1a +/- mice were analyzed for the expression of apoptosis markers (caspase 3, 8 and 9). Gender differences were observed in the expression levels of the three caspases consistent with some altered activity in the open-field assay. The number of apoptotic cells was significantly increased. We concluded that apoptotic pathways are only partially affected in the pathogenesis of the Cc2d1a heterozygous mouse model.