Hemostatic efficacy of a traditional medicinal plant extract (Ankaferd Blood Stopper) in bleeding control

Sogut O., Erdogan M. O., Kose R., Boleken M. E., Kaya H., Gokdemir M. T., ...Daha Fazla

Clinical and Applied Thrombosis/Hemostasis, cilt.21, sa.4, ss.348-353, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/1076029613504129
  • Dergi Adı: Clinical and Applied Thrombosis/Hemostasis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.348-353
  • Anahtar Kelimeler: Ankaferd Blood Stopper, experimental, hemostasis, heparin sodium, tail bleeding
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

The aim of this study is to assess the in vivo hemostatic effect of Ankaferd Blood Stopper (ABS) on rats using a tail bleeding model. Wistar rats were randomized into 4 groups of 9 each: group 1, control, no pretreatment, irrigated with saline; group 2, no pretreatment, irrigated with ABS; group 3, control, heparin pretreatment, irrigated with saline; and group 4, heparin pretreatment, irrigated with ABS. To control bleeding, compressive dressings were placed after instilling 1 mL of either ABS or saline to the bleeding area. Without heparin pretreatment, ABS shortened hemostasis time by 1.57 minutes and reduced the amount of bleeding by 0.85 g. With heparin pretreatment, ABS shortened hemostasis time by 3.29 minutes and reduced the amount of bleeding by 1.32 g. The ABS was more effective than saline irrigation for treating tail tip bleeding in rats, with or without heparin pretreatment, while also using a compressive dressing.