IN VITRO SYNERGISTIC EFFICACY OF VARIOUS ANTIBIOTIC COMBINATIONS AGAINST MULTI-DRUG-RESISTANT PSEUDOMONAS AERUGINOSA ISOLATES OBTAINED FROM PATIENTS IN INTENSIVE CARE UNITS


Sanal L., Sen S., Cesur S., YILMAZ N.

ACTA MEDICA MEDITERRANEA, vol.32, no.4, pp.1041-1046, 2016 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.19193/0393-6384_2016_4_129
  • Title of Journal : ACTA MEDICA MEDITERRANEA
  • Page Numbers: pp.1041-1046

Abstract

Introduction: Pseudomonas aeruginosa (P. aeruginosa) is one of the most common nosocomial pathogens in intensive care units (ICUs), with an increased prevalence of multidrug resistance in nosocomial infections. The treatment options are very limited in infections caused by multi drug resistant (MDR) P. aeruginosa strains. Combinations of antimicrobials are frequently used in the treatment of MDR P. aeruginosa infections. In this study we investigated the minimum inhibitory concentrations (MICs) of imipenem(IMP), doripenem(DOR), colistin(CO) and polymyxin B (PO) alone and in vitro synergistic activity of carbapenem-polymixin combinations (IMP-CO, DOR-CO and DOR-PO) in MDR P. aeruginosa strains obtained from patients in ICUs.