ACTA MEDICA MEDITERRANEA, cilt.32, sa.4, ss.1041-1046, 2016 (SCI-Expanded)
Introduction: Pseudomonas aeruginosa (P. aeruginosa) is one of the most common nosocomial pathogens in intensive care units (ICUs), with an increased prevalence of multidrug resistance in nosocomial infections. The treatment options are very limited in infections caused by multi drug resistant (MDR) P. aeruginosa strains. Combinations of antimicrobials are frequently used in the treatment of MDR P. aeruginosa infections. In this study we investigated the minimum inhibitory concentrations (MICs) of imipenem(IMP), doripenem(DOR), colistin(CO) and polymyxin B (PO) alone and in vitro synergistic activity of carbapenem-polymixin combinations (IMP-CO, DOR-CO and DOR-PO) in MDR P. aeruginosa strains obtained from patients in ICUs.