The hybrid molecules are one of the powerful tools used in the new drug discovery. In this work, nine perimidine-pyrazole hybrids were designed and synthesized. All structures of the novel compounds were characterized elemental analysis, FTIR, NMR and HRMS. Genotoxic, mutagenic and carcinogenic effects of two of the synthesized compounds were evaluated. The tested compounds could cause chromosomal damage by genotoxic potential and mitotic delay by cytotoxic potential at high concentrations (25-100 mu M).