Research on the protective effect of caffeic acid phenethyl ester on testicular damage caused by cisplatin


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Ceylan T., Kaymak E., CANTÜRK TAN F., YAKAN B.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.50, no.8, pp.2032-2039, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 8
  • Publication Date: 2020
  • Doi Number: 10.3906/sag-2002-58
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.2032-2039
  • Keywords: Caffeic acid phenethyl ester, cisplatin, comet assay, rat, testes, INDUCED NEPHROTOXICITY, INJURY
  • Yozgat Bozok University Affiliated: Yes

Abstract

Background/aim: Cisplatin (CP), a chemotherapeutic drug, causes damage to spermatogenic serial cells, Sertoli cells, and Leydig cells in rat testicles. It was aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE), one of the active ingredients of propolis, in eliminating CP-induced testicular damage.