Risk factor's for ICU-acquired imipenem-resistant Gram-negative bacterial, infections

Akinci E., Collan A., Bodur H., Balaban N., Erbay A.

JOURNAL OF HOSPITAL INFECTION, cilt.59, sa.4, ss.317-323, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.jhin.2004.09.030
  • Dergi Adı: JOURNAL OF HOSPITAL INFECTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.317-323
  • Anahtar Kelimeler: antibiotic resistance, imipenem, Acinetobacter, Pseudomonas aeruginsa, CHROMOSOMAL BETA-LACTAMASE, AERUGINOSA PRODUCING VIM-1, PSEUDOMONAS-AERUGINOSA, ACINETOBACTER-BAUMANNII, NOSOCOMIAL INFECTIONS, CARBAPENEM RESISTANCE, OUTBREAK, EMERGENCE, THERAPY
  • Yozgat Bozok Üniversitesi Adresli: Hayır

Özet

Intensive care units (ICUs) are high-risk areas for infections caused by antibiotic-resistant bacteria. This study investigated the risk factors for ICU-acquired imipenem-resistant Gram-negative infections. It was conducted prospectively in three surgical ICUs and one medical ICU from April to December 2002. ICU-acquired Gram-negative infections were found in 128 patients. Of these, 42 had imipenem-resistant and 86 had imipenem-sensitive Gram-negative bacteria as the cause of infection. According to the univariate analysis results, hospital stay before ICU admission, hospitalization period before ICU admission, length of ICU stay, surgical ICU stay, surgical operation and previous antibiotic use were significant risk factors for the acquisition of imipenem-resistant infections. In the multivariate analysis, length of ICU stay, surgical operation and previous carbapenem use were independently associated with imipenem resistance. (c) 2004 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.