Simultaneous quantitative detection of 10 phthalates in PVC children's toys by HPLC-PDA

Akkbik M., TÜRKSOY V. A., Kocoglu S.

TOXICOLOGY MECHANISMS AND METHODS, cilt.30, sa.1, ss.33-38, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/15376516.2019.1650145
  • Dergi Adı: TOXICOLOGY MECHANISMS AND METHODS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.33-38
  • Anahtar Kelimeler: HPLC-PAD, phthalates, PVC toys, ultrasonic extraction, SOLID-PHASE EXTRACTION, EXPOSURE, METABOLITES, ESTERS, QUANTIFICATION, IDENTIFICATION, MIGRATION, DEVICES, WATER
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

A high-performance chromatography-photodiode array detection (HPLC-PAD) method has been developed and validated for the identification and quantification of ten phthalates; diethyl phthalate (DEP), diallyl phthalate (DAP), benzyl butyl phthalate (BBP), di-n-butyl phthalate (DBP), dihexyl phthalate (DHP), dicyclohexyl phthalate (DCHP), di-2-ethylhexyl phthalate (DEHP), di-n-octyl phthalate (DOP), diisononyl phthalate (DINP) and diisodecyl phthalate (DIDP) in children's PVC toys. The phthalates were extracted from PVC toy sample using ultrasonic extraction with methanol. Quantification analysis was achieved by gradient elution mode using reversed-phase ODS-4 C-18 column with PAD detection at 226 nm. The method has been validated for (BBP, DOP, DINP, and DIDP) and (DEP, DAP, DBP, DCHP, DHP, and DEHP) in the concentration range of 1-100 and 2-200 mg L-1, respectively. The accuracy determined as recovery were 82.85-107.40% with RSD values at 0.8-4.2%. The limits of detection for (DEP, DAP, BBP, DBP, DCHP, DHP, DEHP, DOP, DINP, and DIDP) were 0.02, 0.04, 0.01, 0.03, 0.02, 0.03, 0.03, 0.01, 0.08, and 0.10 mg L-1, respectively.