Mechanism of the beneficial effects of dantrolene sodium on ethanol-induced acute gastric mucosal injury in rats


Buyukokuroglu M., Taysi S., Polat F. , Gocer F.

PHARMACOLOGICAL RESEARCH, vol.45, no.5, pp.421-425, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2002
  • Doi Number: 10.1006/phrs.2002.0951
  • Title of Journal : PHARMACOLOGICAL RESEARCH
  • Page Numbers: pp.421-425
  • Keywords: dantrolene sodium, ethanol, rat, ulcer, antioxidant, FREE-RADICALS, LIPID-PEROXIDATION, ANTIOXIDANTS, STRESS, CA2+, HYDROPEROXIDE, MELATONIN, LESIONS, ASPIRIN, DAMAGE

Abstract

In our study; we examined anti-ulcerogen and antioxidant effects of dantrolene sodium on ethanol-induced gastric lesions in rats. Dantrolene sodium was administered intraperitoneally (i.p.) in several doses, and famotidine was used at a dose of 20 mg kg(-1). It was found that pretreatment with dantrolene sodium at doses of 1, 5 and 10 mg kg(-1) significantly reduced ethanol-induced gastric damage and malondialdehyde levels, and significantly increased antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. We conclude that dantrolene sodium clearly has antioxidant properties and that the protective effect of dantrolene sodium against ethanol-induced gastric mucosal lesion, at least in part, depends upon the reduction in the lipid peroxidation and an increase in the activity of antioxidant enzymes SOD and GSH-Px. (C) 2002 Elsevier Science Ltd. All rights reserved.