Protective effect of saxagliptin against renal ischaemia reperfusion injury in rats

---

Atıf İçin Kopyala

TEKİN S., Beytur A., ÇAKIR M., Taslidere A., ERDEN Y., TEKİN Ç., ...Daha Fazla

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, cilt.128, sa.3, ss.608-618, 2022 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 128 Sayı: 3
• Basım Tarihi: 2022
• Doi Numarası: 10.1080/13813455.2020.1715442
• Dergi Adı: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
• Sayfa Sayıları: ss.608-618
• Anahtar Kelimeler: Dipeptidyl peptidase-4 inhibitor, oxidative stress, saxagliptin, renal ischaemia reperfusion, lipid peroxidation, ACUTE KIDNEY INJURY, ISCHEMIA/REPERFUSION INJURY, SITAGLIPTIN, DYSFUNCTION, INHIBITION, OUTCOMES, CELLS
• Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Saxagliptin is an effective and selective dipeptidyl peptidase-4 (DPP-4) inhibitor. This study was designed to determine possible protective effects of saxagliptin against damage caused by renal ischaemia/reperfusion (I/R) in rats. In this study, 40 rats were divided into 4 groups (n = 10 for each). Group 1 (Control), Group 2 (I/R) in both kidneys ischaemia of 45 min was performed, and then reperfusion was applied for 24 h. Saxagliptin (Group 3: 2 mg/kg and Group 4: 10 mg/kg) was administered by oral gavage to the animals in treatment groups, before the I/R. Saxagliptin decreased the markers (BUN, Cre, NGAL, KIM-1 and IL-18) of acute renal damage in blood and kidney tissue. Saxagliptin provided increase in antioxidant enzyme levels and decrease in MDA and apoptosis. Histological results showed that the administration of saxagliptin exhibited a protective effect against renal damage caused by I/R. These results indicates that saxagliptin provide protection against kidney injury caused by I/R.