ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, cilt.29, sa.1, ss.5-11, 2020 (SCI-Expanded)
Background. Methotrexate (MTX) is an antineoplastic agent, which increases the level of reactive oxygen species (ROS) and decreases the level of antioxidants. Lycopene, is a potent antioxidant, which is used because of its protective effect against tissue damage.