Preparation of novel pyrrol-2-one derivatives via an effective synthesis of new oxazole scaffold


KIBRIZ İ. E. , SAÇMACI M. , ŞAHİN E., YILDIRIM İ.

TETRAHEDRON, vol.73, no.14, pp.1795-1802, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 14
  • Publication Date: 2017
  • Doi Number: 10.1016/j.tet.2017.01.046
  • Title of Journal : TETRAHEDRON
  • Page Numbers: pp.1795-1802

Abstract

A convenient procedure for the preparation of oxazole and pyrrole derivatives is described. 2-Amino-1,3-oxazol-2-ones 3a,b were first synthesized from the cyclocondensation reactions of cyanamide (2) with 4-ethoxycarbonyl-5-aryl-2,3-furandione 1a,b, and then new pyrrol-2-ones 5 were synthesized from the reaction of the compounds 3 with various aromatic amines 4. (C) 2017 Published by Elsevier Ltd.