Co-administration of cisplatin and curcumin does not alter mood-associated behaviors

Demir, E.; Oz, M.; Alp, M.; Gergerlioglu, H.; Atalik, Nurullahoglu; Yerlikaya, F.

doi:10.4149/bll_2016_021

Co-administration of cisplatin and curcumin does not alter mood-associated behaviors

Demir E. A., Oz M., Alp M., Gergerlioglu H. S., Atalik N. K. E., Yerlikaya F. H.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.117, sa.2, ss.106-111, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 117 Sayı: 2
Basım Tarihi: 2016
Doi Numarası: 10.4149/bll_2016_021
Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.106-111
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Yozgat Bozok Üniversitesi Adresli: Evet

Özet

OBJECTIVES: Cisplatin (cis-diamminedichloroplatinum (II)) is a widely-used platinum-based chemotherapeutic agent which has dose-limiting side-effects. Also, the drug resistance is another instance that decreases treatment success in cisplatin chemotherapy. The growing body of evidence suggests that curcumin, a polyphenolic compound extracted from the spice turmeric, may exert synergistic effects and sensitize malign cells to cisplatin, while alleviating cytotoxicity-related side-effects. The present study was aimed to investigate mood-associated interactions between cisplatin and curcumin.