Co-administration of cisplatin and curcumin does not alter mood-associated behaviors

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Demir E. A., Oz M., Alp M., Gergerlioglu H. S., Atalik N. K. E., Yerlikaya F. H.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.117, no.2, pp.106-111, 2016 (SCI-Expanded) identifier identifier identifier


OBJECTIVES: Cisplatin (cis-diamminedichloroplatinum (II)) is a widely-used platinum-based chemotherapeutic agent which has dose-limiting side-effects. Also, the drug resistance is another instance that decreases treatment success in cisplatin chemotherapy. The growing body of evidence suggests that curcumin, a polyphenolic compound extracted from the spice turmeric, may exert synergistic effects and sensitize malign cells to cisplatin, while alleviating cytotoxicity-related side-effects. The present study was aimed to investigate mood-associated interactions between cisplatin and curcumin.