Changes in the expression and methylation levels of the MMP-2, MMP-9, TIMP-1, TIMP-2 and VEGF-A genes in children with acute lymphoblastic leukemia

Inandiklioglu N., DEMİRHAN O., Bayram I., Tanyeli A.

CUKUROVA MEDICAL JOURNAL, cilt.46, sa.2, ss.825-833, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.17826/cumj.856752
  • Dergi Adı: CUKUROVA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.825-833
  • Anahtar Kelimeler: Acute lymphoblastic leukemia, MMP, TIMP, VEGF-A, ENDOTHELIAL GROWTH-FACTOR, BONE-MARROW, MATRIX METALLOPROTEINASES, ANGIOGENESIS
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Purpose: The aim of this article is to show the expression and methylation levels of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and vascular endothelial growth factor (VEGF)genes in patients diagnosed with childhood acute lymphoblastic leukemia (ALL) and their relationship with clinical findings.