Changes in the expression and methylation levels of the MMP-2, MMP-9, TIMP-1, TIMP-2 and VEGF-A genes in children with acute lymphoblastic leukemia


Inandiklioglu N. , DEMİRHAN O., Bayram I., Tanyeli A.

CUKUROVA MEDICAL JOURNAL, vol.46, no.2, pp.825-833, 2021 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.17826/cumj.856752
  • Title of Journal : CUKUROVA MEDICAL JOURNAL
  • Page Numbers: pp.825-833
  • Keywords: Acute lymphoblastic leukemia, MMP, TIMP, VEGF-A, ENDOTHELIAL GROWTH-FACTOR, BONE-MARROW, MATRIX METALLOPROTEINASES, ANGIOGENESIS

Abstract

Purpose: The aim of this article is to show the expression and methylation levels of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and vascular endothelial growth factor (VEGF)genes in patients diagnosed with childhood acute lymphoblastic leukemia (ALL) and their relationship with clinical findings.