Detection of insulin-like growth factor receptor-1 in the human cremaster muscle and its role in the etiology of the undescended testis

ÖZDAMAR M. Y. , Sahin S., ZENGİN K., Seckin S., Gurdal M.

ASIAN JOURNAL OF SURGERY, vol.42, no.1, pp.290-296, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.1016/j.asjsur.2018.02.005
  • Title of Journal : ASIAN JOURNAL OF SURGERY
  • Page Numbers: pp.290-296


Purpose: Previous studies of undescended testis (UT) has focused on insulin-like hormone 3 (INSL3), the genitofemoral nerve, and androgens in the testicular descent. Leydig cells, which are under the control of insulin-like growth factor-1 (IGF1), produce both androgens and INSL3. We aimed to investigate whether insulin-like growth factor receptor-1(IGFR1) exists in the cremaster muscle (CM) complex and is associated with normally descended testis as well as UT cases in humans.