Evaluation of the corneal endothelium by specular microscopy in patients with chronic obstructive pulmonary disease

Songur M. S. , İNTEPE Y. S. , BAYHAN S. A. , BAYHAN H. A. , ÇİFTÇİ B.

CLINICAL RESPIRATORY JOURNAL, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2021
  • Doi Number: 10.1111/crj.13408


Objective The objective of this study is to evaluate the corneal endothelium in patients with chronic obstructive pulmonary disease (COPD) using a specular microscope. Methods The right eyes of 64 patients with a COPD diagnosis and 65 healthy individuals were evaluated. Cell density (CD) (cell/mm(2)), corneal thickness (CT) (mu), hexagonal cell ratio (%), and coefficient of variation (cell area standard deviation/mean cell area, mu m(2)) were analyzed by specular microscopy (SM). Results The CT was significantly reduced in the COPD group compared with the control group (P = 0.021). Moreover, a significant difference was found between the COPD group and the control group in terms of corneal endothelial CD (P = 0.011), hexagonal cell ratio (P = 0.008), and coefficient of variation (P = 0.012). Conclusion The corneal endothelial structure was significantly deteriorated in patients with COPD compared with the control group. SM is a valuable method that could be used in treatment and follow-up of corneal endothelium in patients with COPD.