Effects of ivermectin on cytokine and immunoglobulin levels in sheep Efeitos da ivermectina nos níveis de citocinas e imunoglobulinas em ovinos Efectos de la ivermectina en los niveles de citoquinas e inmunoglobulinas en ovejas

Canbar R., Dik I., USLU M., Ider M., Arslan M., Yazar E.

Revista Colombiana de Ciencias Pecuarias, vol.36, no.4, pp.210-215, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.17533/udea.rccp.v36n4a5
  • Journal Name: Revista Colombiana de Ciencias Pecuarias
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, Veterinary Science Database, Directory of Open Access Journals, DIALNET
  • Page Numbers: pp.210-215
  • Keywords: avermectins, immunity, immunoglobulin E, immunoglobulin G, immunoglobulin M, interferon-α, interleukin-10, interleukin-2, interleukin-6, ivermectin, sheep, tumor necrosis factor-α
  • Yozgat Bozok University Affiliated: Yes

Abstract

Background: Ivermectin may affect the levels of cytokines and immunoglobulins in sheep, considering that avermectins have an effect on the immune system. Objective: To determine whether ivermectin has an effect on cytokines and immunoglobulins in sheep. Methods: After administration of ivermectin to 10 healthy sheep, sheep-specific interferon-α, tumor necrosis factor-α, interleukin-2, interleukin-6, interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin E levels were measured with an ELISA reader. Results: Significant (p<0.05) fluctuations were detected in interleukin-2 and interleukin-10 levels. Transient increases (p<0.05) were measured in tumor necrosis factor-α and immunoglobulin E levels (p<0.05). Conclusion: Ivermectin may affect immune system parameters in healthy sheep; however, the effects of ivermectin administration on infected sheep should be investigated.