Chloroquine Decreased Kir6.2 Immunoreactivity in Chronic Hypoxic Heart

ÜNER A. K., KAYMAK E., DOĞANYİĞİT Z., AKİN A. T., BAŞARAN K. E., ÖZDAMAR S., ...Daha Fazla

BEZMIALEM SCIENCE, cilt.10, sa.2, ss.168-173, 2022 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.14235/bas.galenos.2021.5543
  • Dergi Adı: BEZMIALEM SCIENCE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.168-173
  • Anahtar Kelimeler: Kir6.2, KATP channel, ischemia, heart, ATP, CHANNELS, ADAPTATION
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Objective: Experimental and clinical studies indicate that cardiovascular system diseases have the highest mortality rate. One of the major factors underlying this high mortality rate is hypoxia. The inward rectifying potassium channel 6.2 (Kir6.2) plays a key role in the adaptation and metabolic regulation of cardiac tissue to hypoxia. In this study, the effect of chloroquine on Kir6.2 expression in heart tissue exposed to moderate chronic hypoxia was investigated.