DBU-catalyzed, aromatization-oriented, regioselective domino synthesis of 2-aminopyrimidines from beta-dicarbonyl compounds, DMF-DMA, and cyanamide

ÜNGÖREN Ş. H., Boz S.

MOLECULAR DIVERSITY, vol.21, no.4, pp.925-932, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1007/s11030-017-9770-7
  • Journal Name: MOLECULAR DIVERSITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.925-932
  • Keywords: DBU, Domino synthesis, 2-Aminopyrimidine, Cyanamide, beta-Dicarbonyl compound, MCR, Four-component, 2-DIMETHYLAMINOMETHYLENE-1,3-DIONES, DINUCLEOPHILES
  • Yozgat Bozok University Affiliated: Yes

Abstract

A multicomponent domino synthesis has been developed for the preparation of 2-aminopyrimidines from beta-dicarbonyl compounds, N,N-dimethylformamide dimethyl acetal, and cyanamide. The protocol was used for the regioselective preparation of 4-amide/ester/ketone substituted 2-aminopyrimidines. Twelve 2-aminopyrimidines were isolated in good yields (56-93%).