SAKARYA UNIVERSITY JOURNAL OF SCIENCE, vol.26, no.4, pp.768-775, 2022 (Peer-Reviewed Journal)
The ulcer is a vital disease that unfavorably affects human health globally. Helicobaster pylori,
which causes ulcers and some stomach disorders, survives by using the urease enzyme. Metal
coordination complexes (MCCs) are used in numerous industrial areas and the health field.
Cyanide bridged metal complexes are also applied in several applications. In the current study,
antibacterial characteristic of (C1), [Ni(bishydeten)2Ag(CN)2][Ag(CN)2].H2O), and (C2),
([Ni(hydeten)2Ag(CN)2][Ag(CN)2], MCCs were analyzed by disk diffusion, broth dilution and
urease enzyme inhibition assays were performed. As a result of both antibacterial tests, C1 and
C2 were observed to provide favorable effects. The synthesized compounds have effective
inhibitory potential with IC50 values between 26.65±1.21 and 12.37±0.87 µM for urease.