Metal-containing Coordination Complexes (MCCs): Assessment of Biological Activity with Helicobacter pylori Caused Gastric Ulcer

Kısa D., Ceylan Y., Özkan M., Durgun S., Korkmaz N.

SAKARYA UNIVERSITY JOURNAL OF SCIENCE, vol.26, no.4, pp.768-775, 2022 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 26 Issue: 4
  • Publication Date: 2022
  • Journal Name: SAKARYA UNIVERSITY JOURNAL OF SCIENCE
  • Journal Indexes: Academic Search Premier, Business Source Elite, Business Source Premier, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.768-775
  • Yozgat Bozok University Affiliated: Yes

Abstract

The ulcer is a vital disease that unfavorably affects human health globally. Helicobaster pylori, which causes ulcers and some stomach disorders, survives by using the urease enzyme. Metal coordination complexes (MCCs) are used in numerous industrial areas and the health field. Cyanide bridged metal complexes are also applied in several applications. In the current study, antibacterial characteristic of (C1), [Ni(bishydeten)2Ag(CN)2][Ag(CN)2].H2O), and (C2), ([Ni(hydeten)2Ag(CN)2][Ag(CN)2], MCCs were analyzed by disk diffusion, broth dilution and urease enzyme inhibition assays were performed. As a result of both antibacterial tests, C1 and C2 were observed to provide favorable effects. The synthesized compounds have effective inhibitory potential with IC50 values between 26.65±1.21 and 12.37±0.87 µM for urease.