Genetic diversity of Leishmania tropica: Unexpectedly complex distribution pattern.

Charyyeva A., Çetinkaya Ü., Özkan B., Şahin S., Yaprak N., Şahin I., ...More

Acta tropica, vol.218, pp.105888, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 218
  • Publication Date: 2021
  • Doi Number: 10.1016/j.actatropica.2021.105888
  • Journal Name: Acta tropica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Communication Abstracts, EMBASE, Geobase, MEDLINE, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.105888
  • Keywords: Cutaneous leishmaniasis, ITS1, Haplotype diversity, Phylogeography, CUTANEOUS LEISHMANIASIS, VISCERAL LEISHMANIASIS, EPIDEMIOLOGY, DNA
  • Yozgat Bozok University Affiliated: Yes


In this study, we characterized a collection of clinical samples obtained from Syrian and Turkish patients with cutaneous leishmaniasis using internal transcribed spacer 1 (ITS1) sequences. All obtained sequences belonged to Leishmania tropica. Combining them with those available from GenBank allowed us performing a broad-scale analysis of genetic diversity for this species. We demonstrated that L. tropica has a complex phylogeographic pattern with some haplotypes being widespread across endemic countries and others restricted to particular regions. We hypothesize that at least some of them may be associated with alternative vectors or animal reservoirs.