Research Information System
PAKISTAN JOURNAL OF MEDICAL SCIENCES, vol.27, no.3, pp.682-685, 2011 (SCI-Expanded)
Recurrent miscarriage, the occurrence of three consecutive first-trimester losses of pregnancy, affects 1-3 % of pregnant women. The purported causes of recurrent miscarriage include chromosomal abnormalities, thrombophilia, metabolic disorders, anatomical and immunological disturbances. At present, the only recommended investigations are testing for lupus anticoagulant and anticardiolipin antibody levels to diagnose the antiphospholipid syndrome, an acquired thrombophilia and the karyotyping of both parents for chromosomal abnormalities. The Antiphospholipid Syndrome (APS) is an autoimmune disorder characterized by thrombosis, recurrent loss of pregnancy combined with laboratory tests that indicate the presence of antibodies against phospholipid binding proteins.