Akademik Veri Yönetim Sistemi
International Journal of Clinical Practice, cilt.2026, sa.1, 2026 (SCI-Expanded, Scopus)
Objective: This study was designed to evaluate the relationships of the C-reactive protein (CRP)/albumin ratio (CAR), platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), prognostic nutritional index (PNI) values, and clinical parameters in patients with fibromyalgia (FM) syndrome. Methodology: The study population consisted of 103 women with FM and 102 healthy women recruited as controls within a cross-sectional study design. Participants were evaluated with the FM Impact Questionnaire (FIQ), visual analog scale (VAS), and Short Form-36 (SF-36). Complete blood count, CRP, and albumin tests were performed, and CAR, NLR, PLR, and PNI values were calculated. Results: CRP, neutrophil, and CAR values were significantly higher in FM patients (p = 0.020, p = 0.035, and p = 0.017, respectively). Albumin, platelet, lymphocyte, NLR, PLR, and PNI values were similar between the groups (all p > 0.05), indicating that these parameters do not appear to discriminate between patients with FM and control subjects. Only CRP (cutoff = 2.185, sensitivity = 53.4%, specificity = 69.6%, and AUC [95% CI] = 0.594 [0.513–0.674]) and CAR (cutoff = 0.0966, sensitivity = 33%, specificity = 94.1%, and AUC [95% CI] = 0.596 [0.516–0.676]) showed poor but statistically significant discriminative performance (p < 0.05). Energy–vitality scores of SF-36 were weakly and negatively correlated with CRP and CAR (rho = −0.207, p = 0.036, and rho = −0.209, p = 0.034, respectively). Conclusion: Among the inflammatory and nutritional indices evaluated, only CRP and CAR were modestly but significantly higher in FM patients, whereas NLR, PLR, and PNI showed no significant differences between groups. Although the discriminative performance of CRP and CAR was limited, these routinely available laboratory parameters may provide supportive information regarding low-grade inflammation in patients with FM when interpreted together with clinical findings and symptom severity. However, they should not be considered diagnostic markers or interpreted in isolation. Since albumin levels were similar between groups, the observed difference in CAR appeared to be mainly driven by CRP levels. Given the cross-sectional nature of the study and the modest effect sizes, these findings should be considered hypothesis-generating and interpreted with caution. Future longitudinal investigations involving larger patient groups and multivariable analytical models are needed to better clarify the potential supportive role of these markers in FM.