4. BİTKİ ISLAHI VE GENETİĞİ ÖĞRENCİ KONGRESİ, Niğde, Turkey, 2 - 03 June 2022, pp.9
The centromere is an important dynamic structure for the accurate chromosome segregation during
cell division. The Centromeric Histone H3 (CenH3) protein in the centromere is involved in the
assembly of the kinetochore and is important for elucidating the evolutionary process of the
centromere. CenH3 protein has C-terminal histone fold domain which is conserved. Also CenH3
protein has N terminal tail is which is highly variable. Cid is the homolog of CenH3 protein in
Drosophila which is model organism (Kursel et al, 2016). Cid underwent four independent duplication
during evolutionary process and Cid1, Cid2, Cid3, Cid4, Cid5, Cid6 are Cid proteins (Kursel et al, 2016).
The Cenp-C protein binds to Cid with purpose of recruiting to kinetechore proteins. Cenp-C was
underwent duplication, too (Teixeira et al, 2018). Cenp-C1 and Cenp-C2 are paralogs of Cenp-C in
Drosophila (Teixeira et al, 2018). Subfunctionalization is thought to be the cause of these duplications
(Teixeira et al, 2018). Subfunctionalization can occur is by tissue specific expression.