Illumination of CenH3 Gene in Model Organism Drosophila, and Contribution for Agricultural Studies


Aksoy T., Tek A. L.

4. BİTKİ ISLAHI VE GENETİĞİ ÖĞRENCİ KONGRESİ, Niğde, Turkey, 2 - 03 June 2022, pp.9

  • Publication Type: Conference Paper / Summary Text
  • City: Niğde
  • Country: Turkey
  • Page Numbers: pp.9
  • Yozgat Bozok University Affiliated: No

Abstract

The centromere is an important dynamic structure for the accurate chromosome segregation during cell division. The Centromeric Histone H3 (CenH3) protein in the centromere is involved in the assembly of the kinetochore and is important for elucidating the evolutionary process of the centromere. CenH3 protein has C-terminal histone fold domain which is conserved. Also CenH3 protein has N terminal tail is which is highly variable. Cid is the homolog of CenH3 protein in Drosophila which is model organism (Kursel et al, 2016). Cid underwent four independent duplication during evolutionary process and Cid1, Cid2, Cid3, Cid4, Cid5, Cid6 are Cid proteins (Kursel et al, 2016). The Cenp-C protein binds to Cid with purpose of recruiting to kinetechore proteins. Cenp-C was underwent duplication, too (Teixeira et al, 2018). Cenp-C1 and Cenp-C2 are paralogs of Cenp-C in Drosophila (Teixeira et al, 2018). Subfunctionalization is thought to be the cause of these duplications (Teixeira et al, 2018). Subfunctionalization can occur is by tissue specific expression.