Research Information System
SLOVENIAN VETERINARY RESEARCH, vol.1, no.1, pp.1-10, 2024 (SCI-Expanded)
The objective of this study is to assess the morphological and physiological alterations in the heart resulting from four distinct anesthesia combinations, with midazolam, medetomidine, and dexmedetomidine applied as preanesthetics in White New Zealand rabbits. For the study, a total of 32 white New Zealand rabbits were divided into four different groups. The vertebral heart score was measured in rabbits before (T0 ) and at 5 (T5 ), 10 (T10 ), 30 (T30 ), 50 (T50 ) and 70 (T70 ) minutes during the experiment. Concurrently, measurements were taken for the electrocardiographic parameters, all at consistent time intervals. Heart frequency, respiratory rate, rectal temperature, mean arterial pressure and peripheral blood oxygen saturation were measured for a total of 60 minutes with 5 minutes intervals before and during preanesthesia. The vertebral heart score changed in all groups except the Mid+Med group. In the electrocardiographic assessment, in the Mid+Med, Dex, and Mid+Dex groups, an extension in the duration of the QRS wave and QT interval was observed, while no significant change was detected in the durations of the PR interval and T wave. Conversely, in the Me group, a distinct prolongation was observed in the duration of the P wave. Peripheral blood oxygen saturation values increased, heart frequency, mean arterial pressure and rectal temperature parameters decreased in entire groups. Following a thorough analysis of all the data in this study,it was observed that the morphological and physiological effects on the heart induced by the Mid+Med group resulted in less pronounced changes compared to the other groups.