The effect of systemic isotretinoin treatment on skin biophysical parameters among patients with acne vulgaris


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ÇÖLGEÇEN E., Ozyurt K., Kesikoglu A. F.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.46, no.6, pp.1641-1644, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.3906/sag-1507-31
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1641-1644
  • Keywords: Acne vulgaris, isotretinoin, retinoids, biophysical skin parameters, TRANSEPIDERMAL WATER-LOSS, THERAPY, HYDRATION
  • Yozgat Bozok University Affiliated: Yes

Abstract

Background/aim: Systemic isotretinoin has been widely considered an effective and safe medical treatment for severe and refractory acne for nearly 3 decades. However, it also appears to cause undesirable cutaneous side effects. The aim of this study was to prospectively measure biophysical parameters of skin function among patients with acne vulgaris before and after 3 months of isotretinoin therapy, including pH, temperature, sebum content, skin hydration, and transepidermal water loss.