Cannabinoid type 2 receptor agonist JWH-133, attenuates Okadaic acid induced spatial memory impairment and neurodegeneration in rats

ÇAKIR M., TEKİN S., DOĞANYİĞİT Z., ERDEN Y., Soyturk M., ÇİĞREMİŞ Y., ...Daha Fazla

LIFE SCIENCES, cilt.217, ss.25-33, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 217
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.lfs.2018.11.058
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.25-33
  • Anahtar Kelimeler: Alzheimer's disease, Okadaic acid, Cannabinoid type 2 receptor, JWH-133, ALZHEIMERS-DISEASE, CB2 RECEPTORS, AMYLOID PATHOLOGY, TAU-PROTEIN, MOUSE MODEL, WATER-MAZE, BRAIN
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Aim: Cannabinoid system has various physiological roles such as neurogenesis, synaptic plasticity and emotional state regulation in the body. The presence of cannabinoid type 2 receptor (CB2), a member of the cannabinoid system, was detected in different regions of the brain. CB2 receptor plays a role in neuroinflammatory and neurodegenerative processes. We aimed to determine the possible effect of CB2 agonist JWH-133 in Okadaic acid (OKA)-induced neurodegeneration model mimicking Alzheimer's Disease (AD) through tau pathology.