Cannabinoid type 2 receptor agonist JWH-133, attenuates Okadaic acid induced spatial memory impairment and neurodegeneration in rats


ÇAKIR M. , TEKİN S., DOĞANYİĞİT Z. , ERDEN Y., Soyturk M., ÇİĞREMİŞ Y., ...More

LIFE SCIENCES, vol.217, pp.25-33, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 217
  • Publication Date: 2019
  • Doi Number: 10.1016/j.lfs.2018.11.058
  • Title of Journal : LIFE SCIENCES
  • Page Numbers: pp.25-33
  • Keywords: Alzheimer's disease, Okadaic acid, Cannabinoid type 2 receptor, JWH-133, ALZHEIMERS-DISEASE, CB2 RECEPTORS, AMYLOID PATHOLOGY, TAU-PROTEIN, MOUSE MODEL, WATER-MAZE, BRAIN

Abstract

Aim: Cannabinoid system has various physiological roles such as neurogenesis, synaptic plasticity and emotional state regulation in the body. The presence of cannabinoid type 2 receptor (CB2), a member of the cannabinoid system, was detected in different regions of the brain. CB2 receptor plays a role in neuroinflammatory and neurodegenerative processes. We aimed to determine the possible effect of CB2 agonist JWH-133 in Okadaic acid (OKA)-induced neurodegeneration model mimicking Alzheimer's Disease (AD) through tau pathology.