Akademik Veri Yönetim Sistemi
BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY, cilt.136, sa.2, ss.1-11, 2025 (SCI-Expanded)
Current chelation treatments used for cadmium poisoning may cause some serious side effects. Thus, safer novel treatmentscould be promising for clinical use. This study evaluated the effects of cannabidiol on Cd toxicity. Four groups of 10 mice wereformed: Groups I and III were cadmium-free, while groups II and IV received 50 mg/L cadmium in drinking water. Groups IIIand IV received daily cannabidiol (25 mg/kg) via intragastric gavage. After 30 days, the animals were killed, and blood and tissuesamples were collected. Oxidative stress and inflammation markers, including glutathione, catalase, myeloperoxidase, TNF- α,IL-1β and IL- 6, were analysed using ELISA. Additionally, histological evaluations of the liver, kidney and testis were performed.Cadmium exposure reduced glutathione and catalase levels in the blood, liver, kidney and testis, while increasing myeloperoxi-dase. Cannabidiol mitigated these effects on oxidative stress markers. Cannabidiol also reduced the increase in proinflammatorycytokines. Histopathological analysis revealed reduced liver and kidney damage in cannabidiol-treated groups compared tocadmium-only groups. In addition, histopathological evaluation showed CBD had no protective effect on the testicular tissueagainst Cd toxicity. Our results indicate that cannabidiol protects against some toxic effects of cadmium. If confirmed by futurestudies, cannabidiol may be proposed as a novel treatment for cadmium toxicity.