Swyer-James-MacLeod Syndrome (SJMS) is a rare disease characterized with unilateral hyperlucency and hypo-vascularity in pulmonary radiology. The basic pathology is the constrictive bronchiolitis developing depending on recurrent respiratory tract infections in babyhood. The majority of the patients receive diagnoses of recurrent respiratory tract infections in childhood or in young adulthood periods. SJMS may be easily skipped in discriminative diagnosis if the radiology is not inspected carefully in patients who have obstructive air flow in respiration function tests and who have past smoking history. High-resolution computer tomography (HRCT) of the lungs is the basic imaging method used today for diagnosis. We are presenting a 57-year-old female patient who was misdiagnosed with chronic obstructive pulmonary disease (COPD) for many years.