ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats

Cakir, MURAT; Düzova, Halil; Tekin, Suat; Taslidere, Elif; Kaya, Gul; Çiğremiş, Yılmaz; Ozgocer, Tuba; Yoloğlu, Saim

doi:10.1016/j.lfs.2017.03.022

ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats

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Cakir M., Düzova H., Tekin S., Taslidere E., Kaya G. B., Çiğremiş Y., ...More

LIFE SCIENCES, vol.176, pp.10-20, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 176
Publication Date: 2017
Doi Number: 10.1016/j.lfs.2017.03.022
Journal Name: LIFE SCIENCES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.10-20
Keywords: Okadaic acid, N-(p-amylcinnamoyl) anthranilic acid (ACA), Neurodegeneration, TRPM2 channel, Phospholipases A(2), Alzheimer's disease, SPATIAL MEMORY IMPAIRMENT, CENTRAL-NERVOUS-SYSTEM, ALZHEIMERS-DISEASE, INFLAMMATORY RESPONSES, TRPM2 CHANNELS, BRAIN, A(2), MODEL, DEATH, ACCUMULATION
Yozgat Bozok University Affiliated: No

Abstract

Aim: In recent studies, it has been shown that the Transient Receptor Potential Melastatin-2 Channels (TRPM2) and Phospholipases A2 (PLA(2)) inhibitors may have a protective effect on neurons. This study was aimed to investigate the protective effect of TRPM2 and PLA(2) inhibitor N-(p-amylcinnamoyl) Anthranilic Acid (ACA) in a neurodegenerative model induced by Okadaic Acid (OKA).