Modulation of the excitability of stellate neurons in the ventral cochlear nucleus of mice by TRPM2 channels


BAL R., ÖZTÜRK G., Etem E. O. , ERASLAN E. , Ozaydin S.

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.882, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 882
  • Publication Date: 2020
  • Doi Number: 10.1016/j.ejphar.2020.173163
  • Title of Journal : EUROPEAN JOURNAL OF PHARMACOLOGY

Abstract

Oxidative stress-induced Ca2+ permeable transient receptor potential melastatin 2 (TRPM2) channels are expressed at high levels in the brain, appear to link neuronal excitability to cellular metabolism, and are involved in the pathogenesis of neurodegenerative disorders. We aimed to study the electrophysiological properties of TRPM2 channels in stellate cells of the mouse ventral cochlear nucleus (VCN) using molecular, immunohistochemical and electrophysiological approaches.