Modulation of the excitability of stellate neurons in the ventral cochlear nucleus of mice by TRPM2 channels

BAL R., ÖZTÜRK G., Etem E. O., ERASLAN E., Ozaydin S.

EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.882, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 882
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.ejphar.2020.173163
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Oxidative stress-induced Ca2+ permeable transient receptor potential melastatin 2 (TRPM2) channels are expressed at high levels in the brain, appear to link neuronal excitability to cellular metabolism, and are involved in the pathogenesis of neurodegenerative disorders. We aimed to study the electrophysiological properties of TRPM2 channels in stellate cells of the mouse ventral cochlear nucleus (VCN) using molecular, immunohistochemical and electrophysiological approaches.