High serum levels of neopterin in patients with Crimean-Congo hemorrhagic fever and its relation with mortality

Pinar, Onguru; Ozgur, Akgul; Esragul, Akinci; Halil, Yaman; Gulcan, Kurt; Ayse, AYŞE; Nurhayat, Bayazit; Hurrem, Bodur; Kemal, Erbil; Han, Acikel; Aydin, Cevik

doi:10.1016/j.jinf.2008.03.006

High serum levels of neopterin in patients with Crimean-Congo hemorrhagic fever and its relation with mortality

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Pinar O., Ozgur A. E., Esragul A., Halil Y., Gulcan K. Y., Ayse E., ...More

JOURNAL OF INFECTION, vol.56, no.5, pp.366-370, 2008 (SCI-Expanded)

Publication Type: Article / Article
Volume: 56 Issue: 5
Publication Date: 2008
Doi Number: 10.1016/j.jinf.2008.03.006
Journal Name: JOURNAL OF INFECTION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.366-370
Keywords: neopterin, Crimean-Congo hemorrhagic fever, mortality, risk factors, VIRUS, INFECTION, SEVERITY, MARKER
Yozgat Bozok University Affiliated: No

Abstract

Objective: Neopterin is generated and released in increased amounts by macrophages upon activation by interferon-gamma during cellular immune response. In this study, we aimed to investigate serum neopterin levels in patients with Crimean-Congo hemorrhagic fever (CCHF) and its clinical significance as a predictor factor of mortality.