Akademik Veri Yönetim Sistemi
Hellenic Journal of Obstetrics and Gynecology, cilt.20, sa.3, ss.143-148, 2021 (Scopus)
Purpose: Preeclampsia (PE) is a pregnancy-specific syndrome characterized by placentation disorder
that increases maternal and fetal morbidity and mortality. Overproduction of anti-angiogenic factors such
as soluble fms-like tyrosine kinase receptor 1 (sFlt-1) and soluble endoglin (sEng) and low production
of placental growth factor (Pgf) from angiogenic factors contribute to preeclampsia pathogenesis. In this
study, factors involved in angiogenesis including sEng, Pgf and sFlt1 were investigated for pre-recognition
of preeclampsia.
Methods: A total of 54 pregnant women were included in the study and the patients were divided into
normotensive (n = 25) and preeclampsia groups (n = 29). Both groups demographic characteristics, laboratory parameters, sEng, sFlt1 and placental growth factor levels were compared.
Results: While AST, uric acid, LDH mean values were significantly higher in the study group compared
to the control group (p<0.05), there was no significant difference between the groups in terms of ALT,
creatinin, hemoglobin, leucocyte, and platelet values. sEng, sFlt1 values were significantly lover in the
preeclampsia group compared to the control group (p<0.05).
Conclusion: it is thought that Pgf may have a place in the prediction of preeclampsia in advanced pregnancy weeks, but sFlt-1 and sEng are weak in predicting preeclampsia in advanced pregnancy weeks as well.