Envisioning the role of inwardly rectifying potassium (Kir) channel in epilepsy


Akyuz E., Koklu B., Uner A., Angelopoulou E., Paudel Y. N.

JOURNAL OF NEUROSCIENCE RESEARCH, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Publication Date: 2021
  • Doi Number: 10.1002/jnr.24985
  • Title of Journal : JOURNAL OF NEUROSCIENCE RESEARCH
  • Keywords: abnormal discharge, hyperexcitability, Kir channels, seizure, TEMPORAL-LOBE EPILEPSY, KCNJ10 GENE POLYMORPHISMS, RECTIFIER K+ CHANNELS, GYRUS GRANULE CELLS, TS65DN MOUSE MODEL, GAIN-OF-FUNCTION, GIRK CHANNELS, MAXIMAL ELECTROSHOCK, FUNCTIONAL-CHARACTERIZATION, ALTERED EXPRESSION

Abstract

Epilepsy is a devastating neurological disorder characterized by recurrent seizures attributed to the disruption of the dynamic excitatory and inhibitory balance in the brain. Epilepsy has emerged as a global health concern affecting about 70 million people worldwide. Despite recent advances in pre-clinical and clinical research, its etiopathogenesis remains obscure, and there are still no treatment strategies modifying disease progression. Although the precise molecular mechanisms underlying epileptogenesis have not been clarified yet, the role of ion channels as regulators of cellular excitability has increasingly gained attention. In this regard, emerging evidence highlights the potential implication of inwardly rectifying potassium (Kir) channels in epileptogenesis. Kir channels consist of seven different subfamilies (Kir1-Kir7), and they are highly expressed in both neuronal and glial cells in the central nervous system. These channels control the cell volume and excitability. In this review, we discuss preclinical and clinical evidence on the role of the several subfamilies of Kir channels in epileptogenesis, aiming to shed more light on the pathogenesis of this disorder and pave the way for future novel therapeutic approaches.