Background: Nonsteroidal anti-inflammatory drugs are commonly used in addition to opioids after laparoscopic sleeve gastrectomy (LSG). The aim of this study was to demonstrate the analgesic effect of hyoscine-n-butylbromide, a spasmolytic agent, in addition to different analgesic protocols. Methods: Postoperative analgesia records of 134 patients who underwent LSG were analyzed. Patients were divided into four groups according to additional analgesics used. Paracetamol (Group 1, n = 33), dexketoprofen trometamol (Group 2, n = 34), paracetamol and hyocine-n-butylbromide (Group 3, n = 32), and dexketoprofen trometamol and hyocine-n-butylbromide (Group 4, n = 35). The method of analgesia, the visual analogue scale (VAS), the applied analgesic doses, and patient satisfaction scores and side effects were recorded. Results: The cumulative opioid consumption in Group 1 (352.03 +/- 60.02 mg) was higher than that of Group 2 (291.73 +/- 53.70 mg), Group 3 (186.81 +/- 45.55 mg), and Group 4 (186.51 +/- 46.78 mg) (p < 0.05). In addition, in Group 2 the consumption was higher than that of Groups 3 and 4 (p < 0.05). The patient satisfaction score was lower in Groups 1 and 2 than that of Groups 3 and 4, respectively (p < 0.001). VAS scores for Groups 1 and 2 were higher than that of Groups 3 and 4 (p < 0.001). Conclusion: Addition of hyoscine-n-butylbromide to analgesic protocols improves postoperative patient comfort, decreases VAS scores and opioid consumption in LSG.