Background: Animal welfare raised a great deal of attention and associated with ethical and moral aspects. In animal, evaluation of wellness is a great tackle and has a complex entity. Pain and stress are closely associated with poor animal welfare and animal suffering should be removed in order to achieve wellness. Today, good welfare in animal is defined as the absence of stress, thus most of the welfare studies focused on it. The aim of study was to investigate the effect of dexketoprofen trometamol (DEXT) on stress and oxidative stress in cattle undergoing claw trimming.